An Analysis of Skeletal Abnoramlity in Acute childhood Leukemia

Bone changes seen in one hundred children diagnosed as having acute leukaemia have been analysed and related to difficulties in diagnosis, survival time and atypical forms of bone changes. We found no clear relationship between the presence or type of bone changes at presentation and eventual survival. However, patients who developed bone involvment during the courese of the ilnesss did not do as well. Generalised disease such as neuroblastoma may closely mimic or a solitary lesion may closely resemble a bone sarcoma. The previous publications in this field have been comprehensively reviewed.