Organoindium mediated Csp3–S cross-coupling/migratory allenylation/thioannulation cascade: expedient synthesis of highly substituted thiophene frameworks

An operationally simple, efficient and convenient approach for the synthesis of highly substituted thiophene frameworks has been developed via the organoindium mediated coupling of a-enolic dithioesters and C2eC3 centres of propargylic bromides. The in situ generated propargyl indium species efficiently guides the unusual mode of fusion through an unprecedented Csp 3 eS cross-coupling/