Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells

Isabel Behrens,Patric Stenberg,Per Artursson,Thomas Kissel

Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells

2001

Isabel Behrens
Patric Stenberg
Per Artursson
Thomas Kissel

Purpose. A new mucus-secreting in vitro drug absorption model based on monolayers of goblet-cell like sub-clones of the human colon carcinoma cell line HT29 obtained by methotrexate (MTX) treatment was investigated.

Keywords:

Cancer research
Biochemistry
Mucus
Methotrexate
Goblet cell
Mucus-Secreting Cell
Chemistry
Caco-2
In vitro
Endocrinology
Mucin
Internal medicine
Cell culture

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