PREPARATION AND BIOPHARMACEUTICAL EVALUATION OF NITROFURANTOIN LOADED EUDRAGIT RS100 AND EUDRAGIT RL 100 MICROPELLETS
1999
: The objective of the present investigation was to prepare nitrofurantoin micropellets coated with a combination of Eudragit RS 100 and Eudragit RL100 taken in varying ratios to achieve a sustained nitrofurantoin serum and urinary level over a prolonged period of time without any side effect. The method adopted was phase separation coacervation induced by non-solvent addition. The physical nature of the coating film was improved by a protective colloid, polyisobutylene (0% to 3% w/w). The optimized formulations were extensively evaluated for particle size analysis, Scanning Electron Microscopy, stability studies and finally in vitro and in vivo release studies and their statistical evaluation and correlation.
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