Analyse de la CDT par électrophorèse capillaire : comparaison de deux analyseurs

Abstract Carbohydrate-deficient transferrin (CDT) seems nowadays to be an excellent biochemical marker of an excessive alcohol consumption. Capillary electrophoresis separates efficiently and rapidly the isoforms of transferrin and allows a good representation of different isoforms peaks. We decided to study the equipment influence within this method. We determined CDT values with 2 analysers (P/ACE 5500 et P/ACE MDQ) (Beckman Coulter) for a population of 224 persons including men and women from 1 to 89 years old. Analysis of CDT results for both analysers show a very good correlation. However an average bias can be observed with higher levels for P/ACE MDQ. This bias must be considered for low CDT levels or for normal values establishment.