The 50% effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in children with cyanotic and acyanotic congenital heart disease

Abstract Objectives To determine the 50% and 95% effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in children with cyanotic and acyanotic congenital heart disease. Design A prospective, nonrandomized study. Setting A tertiary care teaching hospital. Participants Patients under the age of 18 months with known or suspected congenital heart disease scheduled for transthoracic echocardiography with sedation. Interventions Patients were divided into a cyanotic group (blood oxygen saturation Measurements and Main Results The 50% effective dose (95% confidence interval) of intranasal dexmedetomidine sedation for transthoracic echocardiography was 3.2 (2.78 to 3.55) μg•kg−1 and 1.9 (1.69 to 2.06) μg•kg−1 in the cyanotic and acyanotic groups, respectively. None of the patients experienced significant adverse events. Conclusion The 50% (95% confidence intervals) effective doses of intranasal dexmedetomidine sedation for transthoracic echocardiography were 3.2 (2.78 to 3.55) μg•kg−1 and 1.9 (1.69 to 2.06) μg•kg−1 in children with cyanotic and acyanotic congenital heart disease.