Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

Jenny Aurielle B. Babon,Megan E. DeNicola,David M. Blodgett,Inne Crèvecoeur,Thomas S Buttrick,René Maehr,Rita Bottino,Ali Naji,John S. Kaddis,Wassim Elyaman,Eddie A. James,Rachana Haliyur,Marcela Brissova,Lut Overbergh,Chantal Mathieu,Thomas Delong,Kathryn Haskins,Alberto Pugliese,Martha Campbell-Thompson,Clayton E. Mathews,Mark A. Atkinson,Alvin C. Powers,David M. Harlan,Sally C. Kent

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

2016

Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D.

Keywords:

Immunology
IL-2 receptor
Type 1 diabetes
Natural killer T cell
Cytotoxic T cell
Autoimmunity
Interleukin 21
Islet
Antigen-presenting cell
Medicine
CD8
Antigen
Biology
T cell

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