Clinical characteristics of gastric mucosa-associated lymphoid tissue lymphoma and the effects of Helicobacter pylori eradication therapy

Objective To review the clinical characteristics of patients with gastric mucosa-associ- ated lymphoid tissue（MALT） lymphoma and to investigate the effects of Helicobacter pylori （lip） eradica- tion therapy in these patients. Methods Clinical data of ninety-five patients with gastie MALT lymphoma were reviewed with respect to their clinical manifestations, endoscopic features, histopathological features and tip infection. The follow-up data of patients treated by Hp eradication therapy were analyzed. The sur- vival curve was calculated with Kaplan-Meier, while the predictive factors for resistance to tip eradiation were then analyzed by using Cox proportional hazards model. Results The clinical manifestations and en- doscopic features of 85 patients with gastric MALT lymphoma were non-specific, tip positive was found in 97.9% （93/95） patients at presentation, and 36 patients were treated by lip eradication with a median follow-up duration of （ 58.1 ± 29.9 ） months. Total remission was achieved in 94.4% （ 34/36）, including 24 complete remission 10 partial remission. Therapy failure occurred in 2 patients. 3-year survival rate of patients treated by tip eradication were 86. 2% （25/29）. Cox multivariate analysis showed that age （ ≥ 60 years） , multiple lesions and non-superficial lesions were independent predictors of resistance to lip eradication therapy. Conclusion Gastric MALT lymphoma is associated with Hp infection. Eradication of lip can effectively induce remission in these patients. Key words: Helicobacter pylori;  Gastric mtwosa-associated lymphoid tissue lymphoma;  Threeyear survival rate;  Clinical Features