TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

Adam Patrick Gregory,Calliope A. Dendrou,Kathrine E. Attfield,Aiden Haghikia,Dionysia K. Xifara,Falk Butter,Gereon Poschmann,Gurman Kaur,Lydia Lambert,Oliver A. Leach,Simone Prömel,Divya Punwani,James H. Felce,Simon J. Davis,Ralf Gold,Finn Cilius Nielsen,Richard M. Siegel,Matthias Mann,John I. Bell,Gil McVean,Lars Fugger

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

2012

Genome-wide association studies in combination with functional analyses identify a genetic variant that explains why anti-tumour necrosis factor therapy, used in several autoimmune diseases, exacerbates multiple sclerosis.

Keywords:

Multiple sclerosis
Genetic association
Necrosis
Common disease-common variant
Tumor necrosis factor alpha
Immunology
Genome-wide association study
Genotype
Allele
Bioinformatics
Biology
Single-nucleotide polymorphism
SNP
Disease

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