New modular structures constructed by click chemistry
2013
Inspired by diferent natural compounds with cytotoxic activity, we synthesised new modular compounds by Click Chemistry, using two kinds of building blocks which can be easily coupled. The Cu(I) catalyzed version of the Huisgen reaction, was the tool selected for the coupling of the building blocks. These compounds have been tested to determine their antiproliferative activity against five human solid tumor cell lines.
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