Clinical observation of propofol and remifentanil inhibit gynecological laparoscopic pneumoperitoneum stress response

Objective The aim of the study is to determine the inhibiting effect of propofol and remifentanil does alone or in combination in women undergoing gynecological laparoscopic pneumopcritoneum stress. Methods Eighty patients with ASA I~II ,receiving selective gynecological iaparoscopic surgery were randomly divided into four groups with 20 patients each. In group A propofol were infusioned before operation,in group B remifentanil were infusioned, in group C propofol and remifentanil were infusioned, in group D nothing were infusioned as a control group. All groups anesthesia were maintained with isoflurane infusion and propofol,vecuronium, fentanyl induced. Results There were significant difference in SBP, HR,SNAP among four groups at pneumoperitoneum after were higher than before pneumoperitoneum (P < 0.05). Pneumopeeritoneum after the index SNAP in group D was higher than those in group A and group C(P < 0.05). There was no significant difference between group B and group D. Pneumoperitoneum after the index SBP, HR in group D were signifi-cantly higher than those three groups(P<0.05).The time of extubation group C and D were significantly shorter than group A and group B(P < 0.05). Conclusion Propofol and remifentanil does alone or in combination may refer to restrain gynecological laparoscopic pneumoperitoneum the stress reaction, but the two combined to better effect. Key words: Propofol; Remifentanil; Gynecological laparoscopic; Stress response