Morphofunctional analysis of the efficacy of verapamil in experimental ischemia

: The authors made a comparative analysis of structural and functional changes of the myocardium of 21 dogs after a 30 minute limitation of the blood circulation in the circumflex branch of the left coronary artery with subsequent 30-minute reperfusion during intravenous administration of verapamil in the period and before the beginning of limitation of the coronary circulation. Verapamil produced an essential cardioprotective effect during its preventive use. The effect was less pronounced when the agent was administered after the development of ischemia.