Excoecarins L and O from the mangrove plant Excoecaria agallocha L.

Abstract Two new beyerene-type diterpenoids ( 1 and 2 ), along with six known metabolites ( 3 - 8 ) were isolated from the twigs and leaves of the mangrove plant Excoecaria agallocha L. collected from coastal areas in Vietnam. The structures and relative configurations of new compounds were established on the basis of HR-ESI-MS, 1D and 2D NMR experiments. Two new metabolites were tested for cytotoxicity against two human cancer cell lines (KB and LU-1), but both compounds did not show significant activity.