Effects of Shexiang Baoxin Pill and Isosorbide Dinitrate on Angina of Coronary Heart Disease: A Meta-Analysis

Objective The aim of this study was to evaluate the evidence for Shexiang Baoxin Pill (SBP) and isosorbide dinitrate (ISDN/Xiaoxintong) use in angina of coronary heart disease. We compared their efficacy in effect rate in angina relief (included significant effect and normal effect) and electrocardiogram (EGC) improving rate. Methods Systematically searched Randomized Control Trials (RCTs) in the Cochrane Library, EMBASE, MEDLINE, PubMed, Wanfang and CNKI databases from 2000 to 2016. According to the Cochrane Handbook for systematic reviews, quality assessment and data extraction were precise. All data were analyzed by using Review Manager 5.3. Results 26 studies total 2,634 cases were included. In SBP groups, the effect rate and electrocardiogram improving rate are 90.0% (1223/1358) and 78.3% (799/1021), higher to the ISDN 73.6% (939/1276) and 60.2% (571/947). Both of the meta-analysis showed the SBP is the better one [ Total effect: OR = 0.30; 95% CI = 0.24–0.37; ECG improved: OR = 0.30 95% CI = 0.30–0.46]. Conclusion Shexiang Baoxin Pill has a significant effect to the Isosorbide Dinitrate in angina of coronary heart disease.