Arginine methylation regulates the p53 response

Martin Jansson,Stephen T. Durant,Er Chieh Cho,Sharon Sheahan,Mariola J. Edelmann,Benedikt M. Kessler,Nicholas B. La Thangue

Arginine methylation regulates the p53 response

2008

Martin Jansson
Stephen T. Durant
Er Chieh Cho
Sharon Sheahan
Mariola J. Edelmann
Benedikt M. Kessler
Nicholas B. La Thangue

The tumour suppressor p53 is subject to complex regulation and arginine methylation is now shown to provide an additional level of control. The protein arginine methyltransferase (PRMT) 5 is recruited by Strap to methylate p53 in response to DNA damage, governing the p53 response.

Keywords:

Protein arginine methyltransferase 5
Methylation
Cell biology
Suppressor
Molecular biology
Arginine
Protein-Arginine N-Methyltransferases
DNA damage
Protein-arginine methyltransferase
Biochemistry
Biology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

350

Citations