Distribution and antitumoral activity of adriamycin combined with warfarin in mice.

The distribution of adriamycin (AM) in C57Bl/6 mice bearing intramuscular Lewis lung carcinoma under the influence of combined treatment with warfarin (W) was investigated by a fluorimetric procedure. AM was injected IV at the dose of 7.5 mg/kg 14 days after tumor transplantation and W was given in the drinking water for 96 h, starting 24 h before AM. No substantial modifications in the serum and tissue distribution of AM fluorescence were observed under combined short-term treatment with W.