Dual inhibition of phosphatidylinositol 3-kinase/mammalian target of rapamycin and mitogen activated protein kinase pathways in non-Hodgkin lymphoma

NHL subtypes are classified based on clinical and histologic characteristics, as well as lymphocyte developmental stage. NHL sub-types include diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL),mantle cell lymphoma (MCL), Burkitt lymphoma (BL), primary effusion lymphoma (PEL) to name just a few. Many lymphomas such as DLBCL, MCL, and AIDS-associated lymphomas are very aggressive and rapidly fatal if unresponsive to therapy. Indolent lymphomas, such as FL are also many times not curable with conventional chemotherapy. Clearly, novel treatment paradigms are needed to improve clinical outcomes of patients with NHL.