Antioxidative stress effects of vitamins C, E, and B 12 , and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Background Several vitamins, including C, E, and B12, have been recognized as antioxidants and have shown hepatoprotective effects against the hepatotoxicity caused by acetaminophen (APAP) overdose. The current investigation aims to study the effect of these vitamins and their combination in protecting the liver from APAP hepatotoxicity in rats.