Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by ·OH

Oxidative damage of the mitochondria plays an important role in generating and developing process of many diseases. Hydroxyl radical (·OH) has been considered an important factor inducing mitochondria damage. Therefore, it has important significance to study and exploit medicines protecting mitochondria damage caused by ·OH. We measured effects of procyanidins preventing mitochondria damage induced by ·OH using spectrophotometry and fluorescent polarimetry. The results showed that procyanidins increased effectively membrane lipids fluidity of damaged mitochondria,decreased significantly the mitochondria swelling and lipid peroxidation product formation. As a result,procyanidins can maintain the integrity of structure and function of mitochondria. Above results can provide new data for further exploitation of procyanidins.