OP0310 Pregnancy outcome in women with systemic lupus erythematosus, a multicenter cohort-study

Background Systemic lupus erythematosus (SLE) predominantly affects women during their fertile period. During pregnancy SLE patients are prone to pregnancy complications and may experience increased disease activity. Objectives To investigate disease activity around/during pregnancy and pregnancy complications in a European cohort according to antiphospholipid antibody (aPL) status. Additionally data on lifetime pregnancy outcomes and comparison of first and consecutive pregnancies were analyzed. Methods All ongoing pregnancies of >16 weeks gestation of SLE patients (according to the ACR revised criteria) receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000–2015 were included. Disease activity (using SELENA-SLE(P)DAI around and during pregnancy), flare rate according to the SELENA- SLEDAI definitions and pregnancy complications were assessed by medical chart review. Results From 96 women (84% Caucasian) 144 pregnancies were included. Before ( Conclusions This is the first study in patients with SLE demonstrating that incidence rates of pregnancy complications do not decrease in consecutive pregnancies compared to first pregnancies, in contrast to findings in the general population. Except for HELLP-syndrome, pregnancy complications were not significant different between aPL groups. Despite overall low disease activity and the absence of aPL in the majority of patients, almost half of the patients developed a complication during their pregnancies. Disclosure of Interest B. Blomjous: None declared, C. Abheiden: None declared, S. Kroese: None declared, J. van Laar Grant/research support from: MSD, Pfizer, Roche, Eli Lilly, BMS and Crescendo, R. Derksen: None declared, I. Bultink: None declared, A. Voskuyl: None declared, A. Lely: None declared, M. de Boer: None declared, J. de Vries Grant/research support from: Pfizer, R. Fritsch-Stork: None declared