A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea

Humberto Morales-Loredo,David T. Jones,Adelaeda Barrera,Perenkita Mendiola,Joshua Garcia,Carolyn E. Pace,Minerva Murphy,Nancy L. Kanagy,Laura V. Gonzalez Bosc

A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea

2019

Humberto Morales-Loredo
David T. Jones
Adelaeda Barrera
Perenkita Mendiola
Joshua Garcia
Carolyn E. Pace
Minerva Murphy
Nancy L. Kanagy
Laura V. Gonzalez Bosc

Obstructive sleep apnea (OSA) is characterized by recurrent episodes of pharyngeal collapse during sleep resulting in intermittent hypoxia (IH), and is associated with high incidence of hypertensio...

Keywords:

Cardiology
Sleep apnea
Diabetes mellitus
Endothelin receptor
Obstructive sleep apnea
Macitentan
Biochemistry
Kidney disease
Biology
Intermittent hypoxia
Receptor
Internal medicine

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