Clinical Profile and Outcome of IgA Nephropathy from a Tertiary Care Hospital in North India.

Aim: To study the clinical profile and outcome of the patients with kidney biopsy diagnosis of IgA Nephropathy (IgAN). Methods: A retrospective study of the patients diagnosed IgAN over a period of three and half years. Results: Sixty (13.5%) had a diagnosis of IgAN. Twenty four (40%) had a clinical diagnosis of rapidly progressive glomerulonephritis (RPGN), 20 (33.3%) chronic kidney disease (CKD), 11 (18.3%) nephrotic syndrome, three (5%) acute glomerulonephritis and two (3.3%) asymptomatic urinary abnormalities. Fifty-six (93.4%) patients had hypertension; 15 (25%) patients were presenting as a hypertensive crisis with malignant hypertension in two. Fifteen of the RPGN patients presented with the hypertensive crisis, and all of them had evidence of thrombotic microangiopathy (TMA) on biopsy. Three (5%) patients had secondary IgAN. Patients with the nephrotic syndrome responded to treatment and had a significantly higher renal survival. Patients with interstitial fibrosis and tubular atrophy (IFTA) >/=25% and mesangial hypercellularity score of >0.5 did not respond to treatment. Conclusion: RPGN, CKD, and nephrotic syndrome were the typical manifestation of IgAN. Hypertension and hypertensive crisis were common. Response to treatment was seen in nephrotic syndrome whereas those with IFTA >/=25% and mesangial hypercellularity score of > 0.5 did not respond to treatment.