Detection of Phytoestrogen Metabolites in Breastfed Infants’Urineand the Corresponding Breast Milk by Liquid Chromatography–TandemMass Spectrometry
2020
To date, there has been limited information
on phytoestrogen (PE)
exposure and metabolism in breastfed infants. In the present work,
50 sample pairs of Chinese breastfed infants’ urine and the
corresponding breast milk were collected. The contents of the relevant
PE metabolites in the biosamples were detected via liquid chromatography–tandem
mass spectrometry. The correlations between the PE metabolite contents
in breastfed infants’ urine and those in the corresponding
breast milk were analyzed. The average concentrations of total PE
metabolites in breast milk and urine were 0.27 and 0.23 nmol/mL, respectively.
Genistein and enterolactone levels in the infant urine were positively
correlated with their concentrations in the corresponding breast milk
samples, which implies that urine excretion can be utilized as a noninvasive
parameter for precise genistein and enterolactone intake assessment.
Additionally, the efficiency of PE urine excretion showed significant
differences across infants with different ages, genders, and durations
of pregnancy.
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