Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells
2015
Background
Vertebrate retinal development is a complex process, requiring the specification and maintenance of retinal identity, proliferative expansion of retinal progenitor cells (RPCs), and their differentiation into retinal neurons and glia. The homeobox gene Vsx2 is expressed in RPCs and required for the proper execution of this retinal program. However, our understanding of the mechanisms by which Vsx2 does this is still rudimentary. To define the autonomy requirements for Vsx2 in the regulation of RPC properties, we generated chimeric mouse embryos comprised of wild-type and Vsx2-deficient cells.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
109
References
6
Citations
NaN
KQI