Treating diabetic patients with chemotherapy: Single-center experience of toxicity and outcomes.

9643 Background: Epidemiological evidence suggests diabetics are at increased risk of several cancers, with inferior cancer outcomes. There is little data to describe the experience of diabetic patients during chemotherapy. We have compared outcomes of diabetic patient(pts) with non-diabetics receiving palliative chemotherapy for advanced colorectal cancer (aCRC) in a single centre. Methods: We performed a retrospective case note analysis between 2004 and 2011. Diabetic pts starting first line chemotherapy for aCRC were identified using an electronic patient record database (Patient Pathway Manager) and chemotherapy prescription software (ChemoCare). Data for chemotherapy regimen, acute admissions, subsequent therapy and survival were compared, corrected for age, performance status (PS), comorbidity and initial regimen (single vs combination agent). Results: 146 diabetic pts and 730 controls were included. Median age was 66 years; 94% of diabetic pts had type 2 diabetes, 17% were receiving insulin. Perfor...