[Clinical study on the early and short -- term use of antibiotics with broad spectrum in severely burned patients].

Objective To investigate the prevention and treatment effects of early and short-term use of antibiotics with broad spectrum on postburn severe infection in severely burned patients . Methods Thirty-five burn patients with TBSA from 50% to 95% were enrolled in the study.The patients were divided into early prevention[20 cases,antibiotics were used started from 6 postburn hours(PBH)] and delayed prevention(15 cases,antibiotics were applied after 48 PBH) groups.Plasma levels of LPS,TNFa and IL-8 were dynamically monitored with the concomitant observation of clinical signs of postburn sepsis. Results After major burns,the plasma levels of LPS,TNFα and IL-8 increased evidently and reached the peak values on 3～5 postburn days(PBD). But the levels of all above factors in the early group were obviously lower than those in the delayed group(P0 05～0 01).The incidencies of sepsis and internal organ complications within 2 postburn weeks were much lower in the early group than those in the delayed group (P0 05).The subeschar bacterial quantification on 4～7 PBD was evidently lower in the early group than that in the delayed group (P0 01) . Conclusion Early and short-term use of antibiotics with broad spectrum in severely burned patients could effectively prevent postburn severe infection and lower down the incidence of internal organ complications.