Effect of intracoronary bone marrow-derived mononuclear cell injection early and late after myocardial infarction on CMR-derived myocardial strain

Abstract Background Studies indicate no clear impact of intracoronary injection of bone-marrow unselected mononuclear cells (BM-MNC) after acute myocardial infarction (AMI) on left-ventricular function (LVEF). Strain parameters by cardiovascular magnetic resonance (CMR) have been proposed to be more sensitive to functional changes of the heart. The aim of the present study was to assess changes of global longitudinal (GLS) and circumferential strain (GCS) in a group of patients treated with BM-MNC after AMI. Methods One-hundred and forty-nine patients with successfully reperfused AMI and LV dysfunction (LVEF Results In unadjusted analyses, the absolute change of GLS for the early treatment group from baseline to 4 months was 2.5 ± 4.3 (p  Conclusions Among patients after AMI with successful reperfusion and LV dysfunction, intracoronary infusion of BM-MNC either early or late after AMI did not improve global strain parameters at 4- or 12-months follow-up. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00355186 .