GLP-1 compounds acylated
2006
GLP-1 having at least one non-proteogenic amino acid residue in positions 7 and / or 8 relative to the sequence GLP-1 (7-37), which is acylated with a moiety BU 'to the lysine residue in position 26 where (i) BU 'comprises at least two acidic groups one of which is attached terminally; (Ii) U 'is selected from ** (See formula) ** and ** (see formula) ** wherein m is 0, 1, 2, 3, 4, 5, or 6, n is 1, 2 or 3, s is 0, 1, 2, or 3, t is 0, 1, 2, 3, or 4, p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,18, 19, 20, 21, 22, or 23; and (iii) B is an acidic group selected from ** (See formula) ** where l is 12, 13, 14, 15, 16, 17, 18, 19, or 20.
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