Subclinical Microvascular Lesions among Normoglycemic and Prediabetic Subjects—The PROP-ABC Study

Background: We investigated the occurrence of microvascular lesions in nondiabetic offspring of parents with T2DM enrolled in the PROP-ABC (Pathobiology and Reversibility of Prediabetes in A Biracial Cohort)* study. Design and Methods: We assessed albumin:creatinine ratio (MCR), vibration perception threshold (Vibratron II, Physitemp Instruments Inc, Clifton, NJ) and nonmydriatric retinal images (Zeiss digital camera, Carl Zeiss Meditec AG, Jena, Germany). Results: There were 223 subjects (117 black, 106 white; 70% female), of whom 122 had prediabetes (impaired fasting glucose or impaired glucose tolerance) and 101 had normal glucose regulation (NGR; FPG Conclusions: We here demonstrate a significant association between albuminuria and diverse retinal lesions in a biracial cohort of nondiabetic subjects, and further show relative impairment of vibration perception in prediabetic subjects (NCT02027571). Disclosure N.A. Umekwe: None. I. Owei: None. S. Dagogo-Jack: None.