Formation of target cells in the immunocompetent organ (spleen) of mice with experimental infection caused by influenza A viruses with various properties

: The article presents the data on the time-course of formation of ++virus-pecific target-cells in spleens of mice infected with various types of influenza caused by a virulent viral strain and its avirulent ts-mutation. It was demonstrated that these target-cells occurred in all studied patterns of infection. Their formation turned to be of cyclic character, dose-dependent and closely related with the formation of all known mechanisms of specific and nonspecific cellular defense. The presentation pattern of viral antigens on the surface of these target-cells turned to be variable in the course of the infections evidenced their different recognition in the reactions with the participation of +virus-specific antibodies of effectual cells.