Inhibition of β-Lactamase II of Bacillus cereus by Penamaldic Derivatives of Penicillins
2004
The penamaldic derivatives of amoxicillin, ampicillin, and penicillins G and V, stabilized with Zn2+, were obtained from a methanolic medium. The enzymatic kinetic results show that the these derivatives elicit reversible inhibition of the enzyme metallo-β-lactamase from Bacillus cereus, with inhibition constant values determined at pH 7.0 and 25°C.
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