Cytogenetics of 12 cases of renal adenocarcinoma.

Abstract The cytogenetics of 12 cases of renal adenocarcinoma are presented. Clonal abnormalities were found in nine patients. Worth mentioning are abnormalities of the X chromosome (1 ×) and the chromosomes #1(3 ×), #3(3 ×), #7(4 ×), #8(4 ×), and #14(2 ×). From our data and data from the literature it appeared that the chromosomal regions 3p11–p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.