Formulation and Evaluation of Osmotic Pumps: An Overview

The tablets were prepared by wet granulation technique. Drug was uniformly mixed with mannitol and lactose in a high shear mixer granulator. The dry blend was granulated with povidone, which was dissolved in isopropyl alcohol. The mass was dried at 50°C and sized through American Society of Testing and Materials (ASTM) 20 mesh and mixed with talc and colloidal silicon dioxide. The granules were lubricated with magnesium stearate and compressed into round tablets with standard concave punches (diameter, 9.52 mm) using 27- station rotary compression machine.