Tc-99m hydroxymethylene diphosphonate (HMDP) renal uptake as a surrogate marker of postoperative impairment of glomerular filtration rate in renal tumor patients following nephron-sparing surgery

618 Objectives We investigated Tc-99m hydroxymethylene diphosphonate (HMDP) scintigraphy findings in renal tumor patients from the perspective of postoperative renal dysfunction following nephron-sparing surgery (NSS). Methods Forty-three renal tumor patients (M:F = 28:15, age 53.9 ± 12.5 years) who had undergone Tc-99m HMDP scintigraphy after NSS were enrolled. The patients were divided into HMDP+ or HMDP- groups by visual assessment, and the asymmetric index (ASI) was calculated using a region-of-interest analysis. Total and split glomerular filtration rate (GFR) was assessed using Tc-99m diethylenetriaminepentaacetic acid (DTPA) scintigraphy at baseline and at 3- and 6-months post-NSS. Results High Tc-99m HMDP uptake was observed in the operated kidneys, but this did not persist later than 7 days post-NSS. Split GFR of the operated kidneys at baseline (58.5 ± 9.3 mL/min) was significantly reduced at 6 months post-NSS (40.1 ± 5.9 mL/min, p Conclusions Tc-99m HMDP uptake in operated kidneys within 1 week following NSS is a surrogate marker of GFR impairment over 6 months post-NSS.