The tumor suppressor PTEN has a critical role in antiviral innate immunity

Shun Li,Mingzhu Zhu,Ruangang Pan,Ting Fang,Yuanyuan Cao,Shuliang Chen,Xiaolu Zhao,Cao-Qi Lei,Lin Guo,Yu Chen,Chun-mei Li,Eija Jokitalo,Yuxin Yin,Hong-Bing Shu,Deyin Guo

The tumor suppressor PTEN has a critical role in antiviral innate immunity

2016

Shun Li
Mingzhu Zhu
Ruangang Pan
Ting Fang
Yuanyuan Cao
Shuliang Chen
Xiaolu Zhao
Cao-Qi Lei
Lin Guo
Yu Chen
Chun-mei Li
Eija Jokitalo
Yuxin Yin
Hong-Bing Shu
Deyin Guo

PTEN functions as a tumor suppressor. Guo and colleagues now find PTEN also serves a critical role in antiviral innate immunity by inducing the production of type I interferon.

Keywords:

Immunology
Biology
PTEN
Innate immune system
Suppressor
Phosphorylation
Interferon
Interferon type I
HEK 293 cells
Pattern recognition receptor
Transcription factor
RIG-I

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