GW26-e2456 Orphan Nuclear Receptor Nur77 deletion exacerbates low shear stress-induced carotid artery remodeling in mice

Carotid artery remodeling, also defined as intima-media thickening, is an important predictive indicator for human cardiovascular disease. Chronic changes in shear stress contribute to vascular remodeling. Orphan nuclear receptor Nur77 is expressed in diseased human vascular tissue, and plays a