Degree of proteinuria as a predictor of severity in diffuse proliferative glomerulonephritis: An experience from Sri Lanka

Acute glomerulonephritis (AGN) or infection-related glomerulonephritis (IRGN) is the leading cause of acute nephritic syndrome in developing countries. We examined for differences in histopathological pattern and severity of injury in 48 patients with IRGN, categorized by the degree of proteinuria as nonnephrotic and nephrotic range, and compared the levels of serum albumin and degree of tubular injury between the two groups. Patients with nephrotic range proteinuria had a more severe glomerular and tubular injury and had double contours more often than patients with nonnephrotic range proteinuria.