Proposed Diagnostic Criteria for the Brugada Syndrome

(see 3,4 for review). TheBrugada syndrome is a familial disease displaying anautosomal dominant mode of transmission with incom-plete penetrance and an incidence ranging between 5 and66 per 10 000. In regions of Southeast Asia where it isendemic, the clinical presentation of Brugada syndromeis distinguished by a male predominance (8:1 ratio ofmales:females) and the appearance of arrhythmic eventsat an average age of 40 years (range: 1 to 77 years)