STATUS OF SERUM FREE FATTY ACID (FFA) LEVEL IN OBESE PERSON AND ITS ASSOCIATION WITH DM TYPE -II

Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type -II. Insulin resistance is increased by different factors but FFA is the most common factor to increase insulin res istance. The hallmarks are abdominal obesity, increased insulin resistance and decreased glucose tolerance. Most of the obese people (80%) are DM Type-II but all obese are not diabetic, why? Aim of this study was to studied the FFA level in obese without DM Type-II verses obese with DM Type-II subjects. Subjects were taken from OPD & IPD, Department of Medicine, SRMS, IMS Bareilly (U.P.) India, of both sexes, coming from reasonable distances around Bareilly city. They were from lower and middle class of rural area having moderate physical activities, with vegetarian as well as non -vegetarian dietary habits and were obese as per new Asian BMI guide lines and have symptoms of diabetes. Subjects were not on any drug treatment before taken blood sample. Serum FFA level estimated by ELISA method and Blood sugar was estimated by GOD-POD method. FFA level in obese without DM Type-II verses Obese with DM Type-II were either normal or below normal so we concluded that FFA level was not so much related with insulin r esistance in this study group.