THE ANALYSIS OF THE RELATIONSHIP BETWEEN INFLAMMATION, DEPRESSION AND SUICIDAL BEHAVIOR

Major Depressive Disorder is in direct connection with serotonin, noradrenaline, and dopamine but the exploration of the role that inflammation has in depression has drawn to new conclusions that come in completion of the etiopathogenesis of depression. Material and methods: We have made a retrospective study consisting of a statistical comparative analysis that targets the patients committed to the Vth Clinic of the “Socola” Institute of Psychiatry from Iasi, between 2010-2017, diagnosed with major depressive disorder. There have been analyzed: demographic data, the intensity of the depression measured on the Hamilton scale, VSH values, and the suicidal associated risk. Results: There is a cumulation of factors that can determine the bidirectional relationship between depression and inflammation. The mechanisms that are at the base of it are not fully known but for women with associated suicidal risk from 2010, the elevated values of HAMD were associated with the higher values of VSH, that means at least for women, that depression is associated with a higher degree of inflammation. Conclusions: From the statistical analysis of the studied groups, the average value of HAMD was relatively constant as well in men and women, without considerable variations over the seven years. The difference consists in a stronger association between the women with severe depression and a higher VSH, over men, whereas we can observe lower VSH values, but with tendencies towards the superior limit, that supports an association between depression with the inflammation status, especially in patients with suicidal risk.