Antimicrobial activity of N-hydroxyalkyl 1,2-benzisothiazol-3(2H) -ones and their thiono analogues

Summary N -Hydroxyalkyl derivatives of 1,2-benzisothiazol-3(2 H )-one and 1,2-benzisothiazol-3(2 H )-thione have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were active against selected fungi and Gram-positive microorganisms. Interesting activity was observed against the anaerobic strain Clostridium perfringens . Generally the more active compounds belong to the class of 1,2-benzisothiazol-3(2 H )-ones. The retardation matches R M of the compounds was also evaluated but the results obtained show that lipophilicity has only a minor effect on the antimicrobial activity.