Clinical outcomes of pelvic biomimetic electrostimulation in patients with thin endometrium undergoing frozen-thawed embryo transfer

Objective To investigate the clinical outcomes of pelvic biomimetic electrostimulation in patients with thin endometrium undergoing frozen-thawed embryo transfer (FET) . Methods A total of 596 patients with thin endometrium undergoing FET assisted pregnancy were randomly divided into a control group and a study group depending on whether or not they received pelvic biomimetic electrostimulation. The control group (n=400) were subjected to artificial cycles for endometrial preparation prior to FET. The study group (n=196) , in addition to the endometrial preparation, was given pelvic biomimetic electrostimulation as an intervention. The general conditions, basic hormone levels, intimal thickness before and after pelvic floor treatment, embryo implantation and clinical pregnancy rates were compared between the two groups. Results There was no significant differences in the general conditions, basic hormone levels, and endometrial thickness of the luteal phase before treatment between the two groups (P>0.05) . After biomimetic electrostimulation, the value and magnitude of increase in intima thickness on the day of FET were significantly greater in the study group compared with the control group [ (8.52±1.44) mm vs (7.47±0.75) mm; (1.43±1.31) mm vs (0.29±0.61) mm, respectively, both P 0.05) . Conclusion Biomimetic electrostimulation can promote the intimal growth in patients with thin endometrium prior to FET, increase the clinical pregnancy rate, reduce the trend of ectopic pregnancy, and improve the clinical outcomes. Key words: Biomimetic electrical stimulation; Frozen-thawed embryo transfer; Thin endometrium