Genomic Analysis Reveals Antibiotic Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae (Saskatchewan, Canada).

Whole genome sequencing was used to identify mutations in antibiotic resistance-conferring genes, to compare susceptibility predictions with minimum inhibitory concentrations and to ascertain strain types in 99 isolates of Neisseria gonorrhoeae Genotypes associated with susceptibility as well as MIC creep or emerging resistance were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline resistant N. gonorrhoeae outbreak and the clonal spread of susceptible isolates in men.