Early development of broadly neutralizing antibodies in HIV-1-infected infants.

Antibodies capable of neutralizing a broad array of HIV-1 viral isolates from different clades have been isolated from some chronically infected individuals, but their development is thought to require several years. In this issue, Julie Overbaugh and her colleagues report that HIV-infected infants also develop broadly neutralizing antibodies—some at 1 year of age—and their occurrence early in life may shed light on HIV vaccine efforts to induce these antibodies.