Oligodendrogliomlarda osteopontin ekspresyon düzeylerinin histolojik derece ve sağ kalım ile ilişkisi

Oligodendrogliomas are diffuse infiltrating gliomas of adulthood. The WHO 2007 classification criteria classifies oligodendrogliomas as well-differentiated tumors (Grade 2) and anaplastic tumors (Grade 3). Osteopontin is a sialic acid-rich phosphoglycoprotein extracellular matrix component and it is an immune marker shown to be associated with parameters such as grade and recurrence in different tumors. The purpose of this study was to investigate the relationship between osteopontin and histological grades, recurrence and survival in the oligodendroglioma cases by analyzing its expression rates. Twenty-seven cases of oligodendroglioma operated at the Turkish Ministry of Health Ankara Diskapi Education and Research Hospital, Brain Surgery Clinic between 2008 and 2011 and diagnosed at our hospitals’ pathology clinic were included in the study. Fourteen cases were diagnosed as low-grade (Grade 2, WHO 2007) oligodendroglioma and 12 as high-grade (anaplastic, Grade 3, WHO 2007), and one case was evaluated as glioblastoma with oligodendrogliomal component (Grade 4, WHO 2007). Osteopontin staining density was below the 25% in 10 cases. Nine out of those 10 cases were low-grade oligodendroglioma and one was high-grade. Immunostaining below the 25% was observed in the remaining five low-grade cases. On the basis of histological grade and expressions of osteopontin, density of staining was significantly higher in the high-grade tumors (p<0.01). Osteopontin expression scores were significantly high in high-grade tumors (p<0.05). A significant correlation in the same direction was determined between staining percentage and intensity of staining (r=0.790 and p<0.001). In conclusion, osteopontin expression rates could be associated with histological grades, recurrence and survival of oligodendriomas and could be used as a predictive value