Soybeen Milk Reduces Insulin Resistant in Rattus norvegicus of Type 2 Model Diabetes Mellitus

Type 2 Diabetes melitus (T2DM) is characterized by hyperinsulinemia and hyperglicemia. Soy bean Milk is high nutrient drink especially its proten contain. Several researches demonstrated that soy bean protein decrease plasma insulin and blood glucose level. The aim of this study is to investigate the effect of soy bean milk in reducing insulin resistance of rat T2DM Model. This experimental study used pre and post test control group design. Male Rattus norvegicus wistar strain 8 week old were used as animal model. T2DM rats were constructed by giving high fat diet and continue with injection of low dose of streptozotocin. Rats were divided into 7 groups (1) Negative control group (2) Positive control group (T2DM rat without soy bean milk) (3) T2DM rat that treated with genistein 15 g/kg BW (4) T2DM rat that trated with sooy been milk 10 ml/kgBW/day (5)DMT2 rat that treated with soy been milk 30 ml/kgBW/day (6) T2DM rat that treated with soy been milk was 60 mk/kgBW/day and (7) T2DM rat that treated with soy bean milk 90 ml/kgBW/day. Soy been milk was administrated for 15 days. Data were analyze using One way ANOVA, that continue with Tukey test by SPSS method 13 version. The result showed that there were a significant effect of soy been milk in decreasing glucose serum level (p=0,02) and insulin plasma level (P=0.02) and insulin plasma level (p=0.00). Ahigh increasing of glucose serum level and insulin plasma level occur when rat of DMT2 model was given soy bean milk 90 ml/kgBW/d.