P042 Microbiota stability in vivo and in vitro

Conclusions: These data show a strong correlation of inflammatory responses between the colitis and radiationinduced models of GI injury, with a common TNF-mediated, neutrophilic component in the colon and jejunum, respectively. Further studies will investigate time course and tissue differences. The efficacy of AVX-470m in both models highlights the central role of TNF in GI tract inflammation, and supports the therapeutic potential of an oral anti-TNF antibody in GI inflammatory disease. This project has been funded in part by the Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, under Contract No. HHSO100201100027C. This project has also been supported in part by NIH grant 2R44DK083810 02.