Administration of ticarcillin to patients with severe renal failure.

Ticarcillin half-life was determined in patients with severe renal failure. In nine patients the mean half-life was 13.5 h, while in four patients undergoing haemodialysis the mean half-life was reduced to 4.7 h. It is recommended that 2-gram doses of ticarcillin be given every 8 h with an extra dose midway through an 8-hour dialysis period when treating Pseudomonas pyocyanea infections.