Time-dose-volume considerations in iodine-125 interstitial brachytherapy

Abstract Eighty-nine implants with iodine-125 (I-125) seeds in the lymph nodes and other superficial lesions in the head and neck areas were reviewed in order to determine the time-dose-volume relationship. The period required for complete tumor regression, as determined by clinical palpation, was approximately three months after implantation and was independent of matched peripheral dose (MPD) or tumor volume. There was no correlation observed between MPD and tumor control rate ( p