Effect of gestation and lactation exposure to low-dose tributyltin on development of mice offspring.

Objective To explore the effects of gestation and lactation exposure to low dose tributyltin(TBT) on development of offspring of Kunming mice.Methods The healthy adult pregnant Kunming mice were randomly divided into 4 groups,6 in each group,they were given doses of TBT(100,10 and 1 μg/kg) by gavage from days 6 of gestation(GD6)to the end of lactation.The number of pups and the number of male,female of each dams were determined,and the body weight of pups on PNDs 1,3,5,7,14,21 was weighed.The eye opening from PND12 and the testes descent from PND13 and the vagina opening from PND20 were examined.Results Compared with the control group,the gestational body weight gain of dams decreased in 100 μg/kg group(P0.01).The lactational body weight gain,the number of pups and ratio of female and male were no significant difference among groups.The time of eye opening was significantly delayed and the vagina opening was significantly ahead in treatment groups(P0.05,P0.01),and there was a increasing trend in time of eye opening following the TBT dose rising.Conclusion Gestation and lactation exposure to low-dose TBT may have adverse effects on the growth and development of offspring of Kunming mice.